Uni-Logo
You are here: Home People / Staff Dr. Maria Hoernke
Document Actions

Dr. Maria Hoernke

 

Group Leader
 

Department of Pharmaceutical Technology and Biopharmacy
Hermann-Herder-Strasse 9
D-79104 Freiburg i. Br.

Phone: +49 761 203 6343
Fax: +49 761 203 6366

eMail: Maria Hoernke

Room no.: 03 005 A

MHoe_Port_small.jpg

 

 

We are a young, interdisciplinary team in biophysical chemistry and connected to the department of pharmaceutics at Freiburg University. We collaborate with groups in Prague, Halle, Jena, Shanghai.

We work with alternatives to classical antibiotics. Using microcalorimetry, time-correlated fluorescence spectroscopy, monolayers, and other biophysical methods, we investigate the selectivity of antimicrobial polymers for different lipid membranes, and thus organisms.
We measure and model membrane permeabilization, characterize the interactions of the designed antimicrobial compounds, and reach out to microbiology.
 

Open Position

We are looking for motivated colleagues.

Application deadline for a PhD/postdoc position:

October 30th 2019 or until position is filled.

jobs_pt@pharmazie.uni-freiburg.de

 

NEWS

 

1-2019

Ndjali joins us for a project. Welcome!

11-2018

DFG funds our project about Selectivity in Membrane Permeabilization for 3 years.

9-2018

We are happy to welcome Shuai for her PhD project and Annika for her practical term!

5-2018

Anja wins another Poster Award. Well done!

3-2018

Anja wins a Poster Award. Congratulations!

1-2018

Our paper about Quantified Membrane Permeabilization is out.
ACS Nano

3-2017

The Daimler & Benz Foundation supports our research on lipid clustering for two years.

   

 

Current research

 
Since October 2015 Dr. Maria works at the Department of pharmaceutical technology and at the Centre for Biological Signalling Studies (BIOSS) at the Albert-Ludwigs-Universität Freiburg (Germany). With her team, she studies antimicrobial lipid selectivity, lipid clustering upon electrostatic interactions and in lectin-membrane interactions.
 

CV 


Dr. Maria Hoernke studied chemistry at the Martin-Luther-Universität in Halle (Germany) and at Universidad de Burgos (Spain). She specialized in physical chemistry and biophysics.

Her Diploma thesis focused on the interactions of peptides with lipid model membranes and was carried out in 2007/2008 in Halle(S.). For her PhD project, Maria moved to the interfaces department of Max-Planck-Institute of Colloids and Interfaces in Potsdam (Germany) to study the impact of interfaces on amyloid formation of peptides. After receiving her PhD in 2012, she joined the Theory & Bio-Systems department of the same MPI to complement the project with molecular dynamics simulations as a Postdoc. In 2013, Maria joined Göteborgs Universitet (Sweden). She won a Marie Curie IEF fellowship in order to use time resolved X-ray solution scattering to study conformational changes in photoreceptor proteins. She also investigated structural changes in membrane associated proteins by infrared spectroscopy.

Maria is currently speaker of the section 'Membrane Biophysics' of Deutsche Gesellschaft für Biophysik e.V.
http://www.dgfb.org/de/ueber-dgfb/sektion-2.html


Publications


List of publications
 

Research topics 

  • biophysics of lipid membrane models
  • peptide-membrane interactions
  • permeabilization of lipid membranes
  • antimicrobial activity
  • lipid selectivity
  • conformational changes and orientation of mebrane-bound, surface-bound and soluble proteins or peptides
  • surface-sensitive biophysical methods

 

Methods

  • Differential scanning calorimetry
  • Isothermal titration calorimetry
  • Fluorescence spectroscopy
  • X-ray solution scattering (SAXS/WAXS, time-resolved X-ray scattering)
  • UV/VIS spectroscopy
  • Infrared spectroscopy
  • Circular dichroism
  • Dynamic light scattering


Monolayer techniques

  • Infrared reflection absorption spectroscopy (IRRAS)
  • Grazing incidence X-ray diffraction reflectometry (X-ray and neutrons)
  • Total reflection X-ray fluorescence


Computational methods

  • MD simulations

 

Personal tools