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PD Dr. Andrea Allmendinger

Group Leader
Mailing address: Department of Pharmaceutical Technology and Biopharmacy
Sonnenstrasse 5
D-79104 Freiburg i. Br.
Email address: Andrea Allmendinger
LinkedIn Profile: Andrea Allmendinger


Research interest

We are a growing, young, interdisciplinary team and closely connected to the Pharmaceutical Technology groups of Prof. Heerklotz and Prof. Süss. We believe that we can make a meaningful contribution to a sustainable tomorrow and, motivated by the 17 UN developmental goals, we would like to contribute to 'Good health and Well-being'.


Our Vision

We are aiming for easing access to life-saving, parenterally applied medication for low- and middle-income countries by using the human body as a bioreactor.

Our Mission

We are working on parenteral drug product formulations and device solutions to facilitate product access in countries with limited medical infrastructure. We are in particular interested in mRNA therapeutics incorporated into lipid nanoparticles to achieve our vision and use the human body to produce its own medication (preclinical studies: Stadler and Sahin, Nature Medicine 2017, doi: 10.1038/nm.4356 and Rybakova et al.: Mol. Ther. 2019, doi: 10.1016/j.ymthe.2019.05.012).

We adress three major challenges for access to parenteral medications in 3rd World countries: (1) the cold chain; (2) aseptic product preparation before administration; and (3) cost of goods. While wi do not optimize mRNA constructs, we develop drug product solutions for parenteral delivery with adequate long-term stabilization.

Open Positions

Master student

We are seeking a highly motivated Master student interested in studying mRNA therapeutics. The candidate should habe a Bachelor degree or equivalent in the area of Pharmaceutical Sciences, or related biology and chemical sciences. Previous experience in a laboratory setting is required. For fullest consideration, applicants should send (1) a cover letter with a brief statement of interests, and (2) a CV to: Andrea Allmendinger (May 2021). 

Curriculum vitae Dr. Allmendinger

Download CV Dr. Allmendinger


Featured publications

Download complete list of publications

  • Opportunities in an Evolving Pharmaceutical Development Landscape: Product Differentiation of Biopharmaceutical Drug Products. Allmendinger A*. Pharmaceutical Research. 2021.
  • Glass leachables as a nucleation factor for free fatty acid particle formation in biopharmaceutical formulations. Allmendinger A*, Lebouc V, Bonati L, Woehr A, Kishore RSK, Abstiens K. J Pharm Sci. 2021 Oct: 110(2): 785-795. doi: 10.1016/j.xphs.2020.09.050. PMID: 33035535
  • Comparison of Techniques to Control Ice Nucleation during Lyophilization. Luoma J, Ingham E, Lema Martinez C, Allmendinger A*. Processes. 2020 Nov; 8(11), 1439; doi:10.3390/pr8111439.
  • Tissue Resistance during Large-Volume Injections in Subcutaneous Tissue of Minipigs. Allmendinger A*, Fischer S. Pharm Res. 2020 Sept;37(10):184. doi: 10.1007/s11095-020-02906-9. PMID: 32888065
  • Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations. Haeuser C, Goldbach P, Huwyler J, Friess W, Allmendinger A*. J Pharm Sci. 2020 Jan;109(1):807-817. doi: 10.1016/j.xphs.2019.10.016. PMID: 31622600
  • Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations. Haeuser C, Goldbach P, Huwyler J, Friess W, Allmendinger A*. Pharmaceutics. 2019 Nov;11(11):616. doi: 10.3390/pharmaceutics11110616 .PMID: 31744221
  • Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products. Haeuser C, Goldbach P, Huwyler J, Friess W, Allmendinger A*. J Pharm Sci. 2018 Nov;107(11):2810-2822. doi: 10.1016/j.xphs.2018.06.025. PMID: 30005985
  • Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials. Ditter D, Mahler HC, Gohlke L, Nieto A, Roehl H, Huwyler J, Wahl M, Allmendinger A*. Pharm Res. 2018 May;35(7):146. doi: 10.1007/s11095-018-2421-6. PMID:29796727
  • Characterization of surface properties of glass vials used as primary packaging material for parenterals. Ditter D, Mahler HC, Roehl H, Wahl M, Huwyler J, Nieto A, Allmendinger A*. Eur J Pharm Biopharm. 2018 Apr;125:58-67. doi: 10.1016/j.ejpb.2017.12.018. PMID:29331438
  • Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations. Moorthy BS, Zarraga IE, Kumar L, Walters BT, Goldbach P, Topp EM, Allmendinger A*. Mol Pharm. 2018 Jan;15(1):1-11. doi: 10.1021/acs.molpharmaceut.7b00504. PMID:29182876
  • Hanns-Christian Mahler and Andrea Allmendinger. Stability, Formulation, and Delivery of Biopharmaceuticals. In: Tristan Vaughan, Jane Osbourn, Bahija Jallal (Eds.), Protein Therapeutics. Methods and Principles in Medicinal Chemistry, Wiley‐VCH Verlag GmbH & Co. KGaA, 2017. 469-49. Print ISBN:9783527340866. Online ISBN:9783527699124. doi: 10.1002/9783527699124


Completed thesis

  • Dr. Christina Häuser (PhD thesis, 2019): Investigation of lyophilized antibody formulations to enable short freeze-drying cycles and storage at room temperature
  • Dr. Dominique Ditter (PhD thesis, 2018): Interaction of Parenteral Drug Products with Surfaces of Glass Vials – Studies of Glass Delamination
  • Yuen Li Butt (Master thesis, 2017): Controlled Nucleation during Lyophilisation of Protein Formulations


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