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Semifluorinated Alkanes

Semifluorinated Alkanes as Excipients for Semisolid Topical Formulations

As linear molecules, semifluorinated alkanes (SFAs) are composed of a perfluorocarbon and a hydrogencarbon portion. Being partially fluorinated, these molecules feature special physicochemical properties. Compared to perfluorinated compounds, SFAs exhibit, for example, a lower density anda certain degree of lipophilicity. The special properties of SFAs allow for their application invarious areas of medicine such as, inter alia, in the field of ophthalmology.

At this Department, Dr. Hendrik Hardung investigated in the course of his PhD thesis SFAs as potential excipients for semi-solid drug dosage forms (ointments, creams, gels, pastes). His studies primarily focused on identifying the extent to which the delivery of drugs into the skin from such solid dosage forms may be specifically controlled. These works included to investigate the penetration of SFAs into the skin and their influence on transdermal drug permeation.

Similar to the perfluorinated compounds, SFAs show increased solubility for oxygen. This increased oxygen solubility and its effect on the skinwere studied as well.










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